Curcumin-loaded albumin submicron particles with potential as a cancer therapy: an in vitro study

• Nittiya Suwannasom,
• Netsai Sriaksorn,
• Chutamas Thepmalee,
• Krissana Khoothiam,
• Ausanai Prapan,
• Hans Bäumler and
• Chonthida Thephinlap

Beilstein J. Nanotechnol. 2023, 14, 1127–1140, doi:10.3762/bjnano.14.93

• to confirm the uptake of CUR-HSA-MPs by cancer cells. Our studies revealed that HSA-MPs are potentially promising vehicles for increasing the solubility and bioavailability of CUR. Keywords: albumin submicron particles; cancer therapy; curcumin; drug delivery; Introduction Curcumin (CUR) is a

• to enhance the biological properties and improve cellular uptake of the MPs. The cellular uptake was also measured by fluorescence microscopy as shown in Supporting Information File 1, Figure S1. Conclusion Biodegradable albumin submicron particles were successfully loaded with CUR into protein

• intensity. Loading curcumin in the albumin submicron particles enhanced its cellular uptake by a factor of 1.6. Results are expressed as mean values (n = 3) ± SEM. **p < 0.01; (C) Representative confocal z-stack images demonstrating cellular uptake of FITC-CUR-HSA-MPs (an equivalent concentration of